Both in the Netherlands and in Britain, practices of ‘life story work’ have emerged in nursing for persons with intellectual disabilities. The narrative approach to care and support may at the same time be considered as an attempt to compensate for the ‘disabled authorship’ of many persons with intellectual disabilities and as a sign of controversy with standard practices of diagnosis and treatment that tend to neglect the personal identities of both clients and care givers, their particular historical and relational (...) contexts and their spiritual needs. This paper argues that narrative ethics not only offers an appropriate moral framework for practices of life story work, but that these practices are a narrative ethics in action. Starting with an account of the concept of ‘life story work’ as it has been introduced in nursing practices in the field of intellectual disability, the paper explains its relationship with key characteristics of narrative ethics. The teleological dimension in narrative ethics and in practices of life story work sparks off a dialectic process of understanding of the client and self‐understanding of the care giver. It also invites a respect for life in its openness toward the future and presupposes an openness toward other possible versions of the life narrative. The phenomenological and hermeneutic‐interpretative methodologies in narrative ethics aim at a ‘sudden moment of intimacy’ in relationships of nurses and clients. The ‘epiphany’ of this essential moment of recognition, insight and engagement cannot, however, be brought about by methodology. (shrink)

Rationale, aims and objectives To compare the pharmacotherapeutic approaches to diabetic hypertension of family physicians (FPs) and general practitioners (GPs). Methods A retrospective prescription-based study was conducted in 15 out of a total of 20 health centres, involving 115 primary care physicians – 77 FPs and 38 GPs, representing 74% of the primary care physicians of Bahrain. Prescriptions were collected during May and June 2000 to comprise a study population of 1266 diabetic-hypertensive patients. Results As monotherapy, angiotensin-converting enzyme (ACE) inhibitors (...) (37.9%) and β-blockers (38.3%) were the most commonly prescribed classes of antihypertensives by FPs and GPs, respectively. Calcium channel blockers (CCBs) were ranked third by both categories of physicians. For two-drug combinations, a β-blocker and an ACE inhibitor was the combination of choice for both physician categories. Patients managed by the FPs were more likely to receive a β-blocker–CCB combination (17.4 vs. 14.9%) or a diuretic–ACE inhibitor combination (16.7 vs. 11.4%) and less likely to receive a β-blocker–diuretic combination (11.8 vs. 16.7%) than those managed by the GPs. The proportion of patients receiving antihypertensive combinations was 40.6 and 38.5% for FPs and GPs, respectively. While the GPs prescribed CCB as a monotherapy to the elderly most often, the FPs choice was a β-blocker. Diuretics were less preferred by both FPs and GPs. β-Blocker–ACE inhibitor was again the most preferred combination of both FPs and GPs. FPs prescribed CCB–β-blocker combinations more often than GPs (P = 0.01), whereas CCB–ACE inhibitor combinations were less preferred (P = 0.09). A trend towards excessive use of short-acting nifedipine as monotherapy for elderly patients, both by FPs and by GPs, was noticed. Glibenclamide, alone or in combination with metformin, was the foremost antidiabetic drug prescribed by FPs and GPs. Middle-aged (45–64 years) patients seen by GPs were more likely to receive glibenclamide than those treated by FPs (P = 0.001) and less likely to receive gliclazide (P = 0.01). Combinations of a β-blocker with either glibenclamide or insulin were prescribed considerably more often by GPs.Conclusions Within the same practice setting, a substantial difference was observed between FPs and GPs in terms of preference for different classes of drugs in the management of diabetic hypertension. The compliance of both FPs and GPs was suboptimal; overall, the compliance of the FPs was closer to the recommended guidelines, however. Educational programmes should specifically address these inadequacies in order to improve the quality of health care. (shrink)

Accounting for the Commandments in Medieval Judaism explores the discursive formation of the commandments as a generative matrix of Jewish thought and life in the posttalmudic period. Each study sheds light on how medieval Jews crafted the commandments out of theretofore underdetermined material. By systematizing, representing, or interrogating the amorphous category of commandment, medieval Jewish authors across both the Islamic and Christian spheres of influence sought to explain, justify, and characterize Israel's legal system, divine revelation, the cosmos, and even the (...) divine order. This volume correlates bodies of knowledge-such as jurisprudence, philosophy, ethics, pietism, and kabbalah-that are normally treated in isolation into a single conversation about a shared constitutional concern. (shrink)

The paper attempts to provide a basis for exploring the continued relevance of Catholic social teaching to business ethics, byinterpreting the historic development of a Catholic work ethic and the traditions of Catholic social teaching in light of contemporary discussions of economic globalization, notably those of Robert Reich and Peter Drucker. The paper argues that the Catholic work ethic and the Church’s tradition of social teaching has evolved dynamically in response to the structural changes involved in the history of modern (...) economic development, and thus is well poised to speak to the ethical challenges implicit in the advent of a knowledge-based society. In order to test this thesis, the author sketches an approach to the ethical challenge of corporate downsizing that he believes illustrates the continued relevance of Catholic social teaching to business ethics. (shrink)

To achieve impact, academics need to create personal impact development plans, focused on what and on whom to have an impact and the necessary competencies to do so. Profession and university leaders play a critical role in the successful implementation of such plans.

Health care organizations are increasingly asked to show accountability about their performance. This paper proposes that accountability can best be achieved through evaluative methods that are based on evidence regarding the relationship between processes of care and expected outcomes. Root cause analysis (RCA) is used as an illustration of how a generic method of inquiring can be transformed into an ongoing monitoring, evaluation, user education and accountability strategy. The role of performance indicators, as well as patient and community expectations, is (...) discussed. (shrink)

Type theory is a fast-evolving field at the crossroads of logic, computer science and mathematics. This gentle step-by-step introduction is ideal for graduate students and researchers who need to understand the ins and outs of the mathematical machinery, the role of logical rules therein, the essential contribution of definitions and the decisive nature of well-structured proofs. The authors begin with untyped lambda calculus and proceed to several fundamental type systems culminating in the well-known and powerful Calculus of Constructions. The book (...) also covers the essence of proof checking and proof development, and the use of dependent type theory to formalize mathematics. The only prerequisites are a good knowledge of undergraduate algebra and analysis. Carefully chosen examples illustrate the theory throughout. Each chapter ends with a summary of the content, some historical context, suggestions for further reading and a selection of exercises to help readers familiarize themselves with the material. (shrink)

Since the release of ChatGPT, there has been a lot of debate about whether AI systems pose an existential risk to humanity. This paper develops a general framework for thinking about the existential risk of AI systems. We analyze a two-premise argument that AI systems pose a threat to humanity. Premise one: AI systems will become extremely powerful. Premise two: if AI systems become extremely powerful, they will destroy humanity. We use these two premises to construct a taxonomy of ‘survival (...) stories’, in which humanity survives into the far future. In each survival story, one of the two premises fails. Either scientific barriers prevent AI systems from becoming extremely powerful; or humanity bans research into AI systems, thereby preventing them from becoming extremely powerful; or extremely powerful AI systems do not destroy humanity, because their goals prevent them from doing so; or extremely powerful AI systems do not destroy humanity, because we can reliably detect and disable systems that have the goal of doing so. We argue that different survival stories face different challenges. We also argue that different survival stories motivate different responses to the threats from AI. Finally, we use our taxonomy to produce rough estimates of ‘P(doom)’, the probability that humanity will be destroyed by AI. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Herman Parret and Jacques Bouveresse Introduction. As Rosenberg remarks, " Understanding ... is evidently difficult to understand" (in this volume, p. 29). ...

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

Preliminary summaries of a few empirio?semantical investigations1 concerning such sentences as: can we say x, should we ever (ordinarily) say x, x is self?evident (tautological, contradictory, nonsensical), P does not know what be is talking about, x is voluntary (involuntary) and: that is no excuse.

The essence of expressionism.--The vivifying of space.--A candidate for immortality [Otto Braun]--The machine as slave and master.--The "absolute" poem--A pæau against the age.--The architecture of aspiration.--The visible symphony.--Figures of war and forces of death.--The laughing synthesis.--Activistic architecture.--The dynamic dramatist.--The intensive Shakespeare.--The chromatic "Othello".--The drama on fire.--"The machine-storemers."--The organization of the spirit.

Sex is a fundamentally important biological variable. Recent years have seen significant progress in the integration of sex in many aspects of basic and clinical research, including analyses of sex differences in brain function. Significant advances in the technology available for studying the endocrine and nervous systems are now coupled with a more sophisticated awareness of the interconnections of these two communication systems of the body. A thorough understanding of the current knowledge, conceptual approaches, methodological capabilities, and challenges is a (...) prerequisite to continued progress in research and therapeutics in this interdisciplinary area. Sex Differences in the Brain provides scientists with the basic tools for investigating sex differences in brain and behavior and insight into areas where important progress in understanding physiologically relevant sex differences has already been made. This book was edited and co-authored by members of the Isis Fund Network on Sex, Gender, Drugs and the Brain, sponsored by the Society for Womens Health Research. The book is arranged in three parts. The first part of the book introduces the study of sex differences in the brain, with an overview of how the brain, stress systems, and pharmacogenetics differ in males and females and how this information is important for the study of behavior and neurobiology of both genders. The second part presents examples of sex differences in neurobiology and behavior from both basic and clinical research perspectives, covering both humans and nonhuman animals. The final part discusses sex differences in the neurobiology of disease and neurological disorders. For interested individuals as well as those who are considering conducting research at the intersections of endocrinology, neuroscience, and other areas of biomedicine, the study of sex differences offers exciting and challenging questions and perspectives. This book is intended as a guide and resource for clinicians, scientists, and students. (shrink)

Philosophers of language and linguists tend to think of the interpreter as an essentially non-creative participant in the communicative process. There’s no room, in traditional theories, for the view that correctness of interpretation depends in some essential way on the interpreter. As a result, there’s no room for the possibility that while P is the correct interpretation of an utterance, u, for one interpreter, P* is the correct interpretation of that utterance for another interpreter. Recently, a number of theorists have, (...) for separate reasons, argued in favour of a radically different view of communication – a view in which the interpreter and her context play what should be thought of as a content-creating role. According to such views, natural languages contain what I’ll call interpretation sensitive terms: terms the correct interpretation of which varies across interpreters (or, more generally, contexts of interpretation).3 An interpretation sensitive sentence can have one content relative to one interpreter and another content relative to another interpreter. This paper is a development and (partial) defence of the view that interpretation sensitivity is ubiquitous in natural language. I call the view that there are interpretation sensitive terms content relativism. Before starting the discussion of content relativism, it is worth pointing out that recent attempts to develop semantically motivated versions of truth relativism should be seen as part of this trend of giving the interpreter a more active role. (shrink)

The view defended in this paper - I call it the No-Assertion view - rejects the assumption that it is theoretically useful to single out a subset of sayings as assertions: (v) Sayings are governed by variable norms, come with variable commitments and have variable causes and effects. What philosophers have tried to capture by the term 'assertion' is largely a philosophers' invention. It fails to pick out an act-type that we engage in and it is not a category we (...) need in order to explain any significant component of our linguistic practice. Timothy Williamson (2000) defends a theory of type (i). He says that a theory of assertion has as its goal "[…] that of articulating for the first time the rules of a traditional game that we play" (p. 240). Among those who think we play the game of assertion, there's disagreement about what the rules are. Some think it's a single rule and disagree about what that rule is. Others think the rules change across contexts. According to the No-Assertion view we don’t play the assertion game. The game might exist as an abstract object, but it is not a game you need to learn and play to become a speaker of a natural language. (shrink)

Much work in the philosophy of language assumes that a semantic theory T, for a language L should assign p as the semantic content of an utterance u, by A, of a sentence S in L, if and only if “A said that p” is true. This assumption is mistaken. More generally, the aim of semantics cannot be to capture the extension of English expressions such as “meaning” or “what was said”. This provides support for Davidson’s paratactic theory of indirect (...) speech and for the view that a semantic theory should take the form of a truth-theory. (shrink)

We say that an n-argument predicate P n is finite, if P is a finite set. Note that the set of individuals is infinite! Finite predicates are useful in data bases and in finite mathematics. The logic DBL proposed here operates on finite predicates only. We construct an imbedding for DBL in a special modal logic MPL. We prove that if a finite predicate is expressible in the classical logic, it is also expressible in DBL. Quantifiers are not necessary in (...) DBL. Some simple algebraic properties of DBL are indicated. (shrink)

A semantic theory T for a language L should assign content to utterances of sentences of L. One common assumption is that T will assign p to some S of L just in case in uttering S a speaker A says that p. We will argue that this assumption is mistaken.

Life as a complicated process is composed of causal phenomena. But even if we know the reasons of all that happens in a living organism, we do not know what life really is. The problem of intercausal relation, of “causal structure” remains. The reason why a process takes place, must be found by analysis, causal structures are found by synthesis of the results of this analysis. Causal structures are characterized by two kinds of equilibrium: energetic and specific equilibrium. A state (...) of physical equilibrium is characterized by a minimum of free energy; a biological energetic equilibrium is an organized one, where the vital factors activate the production of energy by each other and force each other to limit that production to the necessary measure. A specific equilibrium is characterized by the properties of its factors, properties by which those factors act as a cause after having received a specific stimulation. Every factor possesses two specific properties, in accordance with the properties of two neighbouring factors, as a link between two other links in a chain . Both forms of equilibrium authorise us to speak of living systems as a “whole”. In the second part of this paper we treat the dynamic aspect of the functions of living systems as a “whole”. This dynamic aspect manifests itself in growth and probably in cortical functions. Blastomeres represent, when isolated, the “whole” of growing potentialities of a germe. In normal contact with each other they restrict themselves to produce a part of that “whole”, in harmony with that which other blastomeres produce. This harmonious restriction can be explained by interaction between all the blastomeres by which every blastomere suppresses in other blastomeres all that it will produce itself. Blastomeres must therefore act on other blastomees not according to their isolate “being”, but according to the influences which they undergo by all other blastomeres, that means according to their “rôle”. There must be a causal net of interaction between all the blastomeres and that net “as a whole” determines every step of growth. Such a net of relation determines also human history and sociology. Materialism only took account of isolated causes, vitalism only of the effect of the net of causal relations without understanding that such a net might be analysed. In reality there is neither materialism nor vitalism.La vie est un phénomène complexe, se composant de différents phénomènes causals, qui un jour peut-être seront réduits à la causalité physique et chimique. Cependant connaitre toutes les causes des phénomènes vitaux ne signifie pas connaître la vie. Le problème de la vie ne se borne pas aux rapports causals, mais implique surtout les rapports intercausals, c'est à dire l'harmonie ou l'équilibre de ses parties constituantes. La vie comme phénomène est provoquée par une „structure causale”. Tandis que les causes sont trouvées par l'analyse, les rapports intercausals doivent être recherchés par la synthèse, c'est-à-dire par la réconstruction de la réalité de l'organisme vivant en se servant des données analytiques. Le système vivant est en équilibre énergétique et spécifique. Les facteurs énergétiques sont interlacés de telle façon, qu'ils s'activent entre eux et qu'ils se forcent entre eux à se resteindre au développement de l'énergie nécessaire. Un équilibre physique c'est l'état d'énergie libre minimum, tandis que l'équilibre biologique c'est un état d'énergie organisée. Dans un équilibre spécifique on ne peut se borner aux effects causals se manifestant par un phénomène. Il faut décrire les rapports des propriétés spécifiques de tous les facteurs; ce sont ces propriétés qui leur permettent d'agir comme cause, lorsqu'-ils sont atteint d'une excitation spécifique. Les facteurs possèdent au moins deux propriétés spécifiques, adaptées à deux facteurs voisins, comme chaque anneau d'une chaine s'adaptant à deux anneaux voisins . Le fait que l'on trouve dans chaque individu ces deux formes d'équilibre nous donne le droit de créer le concept du „tout” par rapport auquel on peut constater l'harmonie de tous les tacteurs.C'est là le „tout statique”, reste encore le „tout dynamique” qui se manifeste par la croissance et probablement par les phénomènes se produisant dans l'écorce cérébrale, base des actes psychiques. Les parties représentent beaucoup de possibilités qui ne se réalisent pas; p.e. les blastomères peuvent représenter le „tout” de l'organisme, tandis qu'ils se borneront dans la croissance normale à la production d'une part de l'individu. Il y a une interaction entre tous les blastomères, de façon que, par la suppression ou par l'activation mutuelle, chaque partie réalise ce que lui laissent les autres et ce qui est en harmonie avec ce que produiront les autres. De cette façon il y aura de l'harmonie dans tout ce qui sera produit. Les parties agissent par cette interaction, non selon leur „être”, en tant que cellule isolée, mais selon leur „rôle” dans le „tout” du germe, rôle qui est déterminé par cette interaction mutuelle universelle. C'est cette interaction qui détermine le „patron causal”, responsable de chaque étappe de la coissance. Ainsi ce ne sont pas les facteus isolés, mais le réseau des rapports établis entre tous les facteurs, qui gouvernent les phénomènes de la croissance. Ce réseau, par activation ou par suppression, détermine à chaque instant les propriétés causales des parties, d'entre toutes les multiples possibilités. Les possibilités étant données dans les cellules, c'est le „tout” du réseau des rapports qui détermine la croissance. Le matérialisme n'a vu que les causes isolées, telles qu'ellés se manifestent dans les expériences des physiciens, grâce à la technique; le vitalisme n'a vu que le „tout”, sans tâcher de l'analyser afin de trouver à sa base le système causal compliqué, que nous avons tâché de décrire. Dans la réalité la théorie du causalisme ni celle du vitalisme le tiennent plus de bout. (shrink)

Historical epistemology is a form of intellectual history focused on “the history of categories that structure our thought, pattern our arguments and proofs, and certify our standards for explanation”. Under this umbrella, historians have been studying the changing meanings of “objectivity,” “impartiality,” “curiosity,” and other virtues believed to be conducive to good scholarship. While endorsing this historicization of virtues and their corresponding vices, the present article argues that the meaning and relative importance of these virtues and vices can only be (...) determined if their mutual dependencies are taken into account. Drawing on a detailed case study—a controversy that erupted among nineteenth-century orientalists over the publication of R. P. A. Dozy'sDe Israëlieten te Mekka —the paper shows that nineteenth-century orientalists were careful to examine the degree to which Dozy practiced the virtues they considered most important, the extent to which these virtues were kept in balance by other ones, the extent to which these virtues were balanced by other scholars’ virtues, and the extent to which they were expected to be balanced by future scholars’ work. Consequently, this article argues that historical epistemology might want to abandon its single-virtue focus in order to allow balances, hierarchies, and other dependency relations between virtues and vices to move to the center of attention. (shrink)